Chromatography for Technetium-99m Radiopharmaceuticals
The goal of this learning
activity is to provide a basic overview of theories,
techniques, and practical aspects applicable to testing
Tc-99m labeled radiopharmaceuticals for radiochemical
purity using chromatography.
This is a knowledge
based activity for pharmacists, technologists, and
technicians. Learning Objectives:
- Explain the
rationale for testing radiopharmaceuticals for
- Explain the
principles of radiochemical purity testing using
- List types of
stationary (solid) phase materials as well as the
care, storage, and use of each.
- List types of mobile
(solvent) phase materials as well as care, storage,
and use of each.
- Explain proper strip
preparation and labeling.
- For commonly
dispensed Tc-99m radiopharmaceuticals:
- Name the solid and mobile phases used in chromatography.
- List the expected location of anticipated radiochemical species
on the solid phase including potential
impurities found in Tc-99m labeled
- List the acceptable limits of labeled radiopharmaceutical for
product release (both USP and in-house limits).
- Calculate the
percentage of the labeled (bound)
- List at least four
procedural checks to be made when chromatography
identifies a “failed” product.
- Given a
chromatographic scenario, hypothesize a logical
explanation of events.
- Explain the impact
that substandard radiopharmaceuticals have on
- Explain methods
necessary to validate alternate chromatography
New Mexico College of Pharmacy
accreditation for this program has expired.
Drug-Radiopharmaceutical Interactions CE
in Renal Imaging -
Interested in the
development of a continuing education program?
Contact Nicki Hilliard at 501-686-6398